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First CRO to develop and validate a bioanalytical method with a LLOQ of 0.05 pg/mL.

Keystone Bioanalytical is the 1st CRO to develop and validate a bioanalytical method with a LLOQ of 0.05 pg/mL. 

First CRO with an AB SCIEX 6500 Triple Quad Mass Spectrometer

Keystone Bioanalytical is the 1st CRO with an AB SCIEX 5500 Triple Quad mass spectrometer with SelexION™ Technology and with multiple AB SCIEX 5500 mass spectrometers. The most sensitive state-of-the-art mass spectrometers offerred by AB SCIEX.

First CRO to equiped with the SelexION® Interface

Keystone Bioanalytical is the only CRO to offer and utilize the AB SCIEX SelexION® interface. This enables Keystone Bionanalytical to provide an added dimension of selectivity.

AB SCIEX 6600 Triple TOF

The AB Sciex triple TOF is capable of high resolution (<10 ppm) mass spectroscopy with or without MS/MS for qualitative and/or quantitative analyses. The instrument provides accurate mass determinations for proteins and metabolites.

High Resolution ICP-MS for Trace Elemental Analysis

Thermo Element 2 high resolution mass spectrometer is capable of ultra-trace elemental analysis. ICP-MS is an essential analytical tool for bioanalysis for organometallics and inorganics, in general. Keystone was the first laboratory to validate an ICP-MS methods for BE studies and ANDA submissions. Keystone has recently added transition metal analysis capabilities for support of protein distribution studies.

Oligonucleotide Analysis

Keystone provides method development, validation, and analysis of oligonucleotides in biological matrices. The techniques uses cross hybridization with fluorescence PNA probes which affords quantitation of oligonucleotides to ≤1 ng/mL in plasma.